| 1. Round | 05/03/2022 | Spartak Trnava | - | ŠKF Sereď | 0:1 | ||||
| 2. Round | 13/03/2022 | FC DAC 1904 | - | Spartak Trnava | 1:1 |  |
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| 3. Round | 20/03/2022 | MFK Ružomberok | - | Spartak Trnava | 0:0 | ||||
| 4. Round | 03/04/2022 | Spartak Trnava | - | Slovan Bratislava | 0:1 | ||||
| 5. Round | 09/04/2022 | Spartak Trnava | - | MŠK Žilina | 1:0 | ||||
| 6. Round | 17/04/2022 | ŠKF Sereď | - | Spartak Trnava | 0:2 | ||||
| 7. Round | 24/04/2022 | Spartak Trnava | - | MFK Ružomberok | 0:0 | ||||
| 8. Round | 01/05/2022 | Slovan Bratislava | - | Spartak Trnava | 1:0 |
Slovakia