| 1. Round | 18/09/2020 | Hamburger SV | - | Fortuna Düsseldorf | 2:1 | ||||
| 3. Round | 04/10/2020 | Holstein Kiel | - | Fortuna Düsseldorf | 2:1 | ||||
| 6. Round | 30/10/2020 | Fortuna Düsseldorf | - | 1. FC Heidenheim 1846 | 1:0 |  |
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| 7. Round | 07/11/2020 | 1. FC Nürnberg | - | Fortuna Düsseldorf | 1:1 | ||||
| 8. Round | 21/11/2020 | Fortuna Düsseldorf | - | SV Sandhausen | 1:0 | |
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| 9. Round | 30/11/2020 | VfL Bochum | - | Fortuna Düsseldorf | 5:0 | ||||
| 10. Round | 04/12/2020 | Fortuna Düsseldorf | - | SV Darmstadt 98 | 3:2 | ||||
| 24. Round | 07/03/2021 | Fortuna Düsseldorf | - | 1. FC Nürnberg | 3:1 | ||||
| 26. Round | 22/03/2021 | Fortuna Düsseldorf | - | VfL Bochum | 0:3 | ||||
| 27. Round | 04/04/2021 | SV Darmstadt 98 | - | Fortuna Düsseldorf | 1:2 | |
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| 29. Round | 18/04/2021 | VfL Osnabrück | - | Fortuna Düsseldorf | 0:3 | ||||
| 30. Round | 21/04/2021 | Fortuna Düsseldorf | - | FC St. Pauli | 2:0 | |
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| 31. Round | 24/04/2021 | SC Paderborn 07 | - | Fortuna Düsseldorf | 2:1 |
Poland