| 15. Round | 22/01/2022 | Gudja United | - | Sliema Wanderers | 1:0 | ||||
| 16. Round | 30/01/2022 | Valletta FC | - | Gudja United | 1:3 | ||||
| 17. Round | 06/02/2022 | Gudja United | - | Birkirkara FC | 0:1 | ||||
| 18. Round | 13/02/2022 | Hamrun Spartans | - | Gudja United | 0:1 | ||||
| 19. Round | 19/02/2022 | Gudja United | - | Balzan FC | 1:0 | ||||
| 20. Round | 26/02/2022 | Floriana FC | - | Gudja United | 2:0 | ||||
| 21. Round | 05/03/2022 | Gudja United | - | Gżira United | 1:2 | ||||
| 22. Round | 12/03/2022 | Gudja United | - | Mosta FC | 1:0 |  |
Ghana