| 4. Round | 11/09/2021 | Dungannon Swifts | - | Coleraine FC | 0:5 | ||||
| 5. Round | 18/09/2021 | Dungannon Swifts | - | Cliftonville FC | 1:3 | ||||
| 2. Round | 28/09/2021 | Ballymena United | - | Dungannon Swifts | 4:3 | ||||
| 9. Round | 16/10/2021 | Glenavon FC | - | Dungannon Swifts | 4:2 | ||||
| 11. Round | 30/10/2021 | Linfield FC | - | Dungannon Swifts | 3:0 | ||||
| 12. Round | 06/11/2021 | Cliftonville FC | - | Dungannon Swifts | 3:0 | ||||
| 15. Round | 26/11/2021 | Glentoran FC | - | Dungannon Swifts | 3:0 | ||||
| 16. Round | 30/11/2021 | Dungannon Swifts | - | Glenavon FC | 0:2 | ||||
| 18. Round | 11/12/2021 | Crusaders FC | - | Dungannon Swifts | 4:0 | ||||
| 19. Round | 18/12/2021 | Dungannon Swifts | - | Ballymena United | 0:2 | ||||
| 21. Round | 01/01/2022 | Dungannon Swifts | - | Linfield FC | 1:6 | ||||
| 23. Round | 22/01/2022 | Dungannon Swifts | - | Portadown FC | 3:1 | ||||
| 24. Round | 25/01/2022 | Glenavon FC | - | Dungannon Swifts | 3:1 | ||||
| 26. Round | 08/02/2022 | Coleraine FC | - | Dungannon Swifts | 2:0 | ||||
| 33. Round | 26/03/2022 | Dungannon Swifts | - | Crusaders FC | 2:4 |
Northern Ireland