| 1. Round | 15/08/2021 | Newtown AFC | - | The New Saints | 1:4 | ||||
| 3. Round | 27/08/2021 | Caernarfon Town | - | Newtown AFC | 0:2 | ||||
| 4. Round | 31/08/2021 | Newtown AFC | - | Cefn Druids | 5:0 | ||||
| 5. Round | 11/09/2021 | Flint Town United | - | Newtown AFC | 4:1 | ||||
| 7. Round | 02/10/2021 | Barry Town United | - | Newtown AFC | 0:3 | ||||
| 8. Round | 09/10/2021 | Newtown AFC | - | Penybont FC | 3:1 |  |
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| 9. Round | 12/10/2021 | Connah's Quay Nomads | - | Newtown AFC | 0:2 | ||||
| 10. Round | 23/10/2021 | Newtown AFC | - | Caernarfon Town | 1:0 | ||||
| 11. Round | 30/10/2021 | Haverfordwest County | - | Newtown AFC | 1:0 | ||||
| 12. Round | 05/11/2021 | Cefn Druids | - | Newtown AFC | 0:5 | ||||
| 13. Round | 09/11/2021 | Newtown AFC | - | Bala Town | 3:3 | ||||
| 14. Round | 19/11/2021 | The New Saints | - | Newtown AFC | 2:0 |
England