1. Round | 17/01/2021 | Atlético Junior | - | Independiente Medellín | 1:0 | ||||
2. Round | 23/01/2021 | Independiente Medellín | - | Patriotas FC | 2:1 | ||||
3. Round | 01/02/2021 | Atlético Bucaramanga | - | Independiente Medellín | 0:1 | ||||
4. Round | 05/02/2021 | Independiente Medellín | - | Millonarios | 0:0 | ||||
6. Round | 14/02/2021 | Independiente Medellín | - | Jaguares de Córdoba | 1:0 | ||||
7. Round | 17/02/2021 | Independiente Medellín | - | Boyacá Chicó | 1:0 | ||||
8. Round | 21/02/2021 | Santa Fe | - | Independiente Medellín | 0:0 | ||||
13. Round | 21/03/2021 | Independiente Medellín | - | Deportivo Pasto | 2:2 | ||||
14. Round | 24/03/2021 | América de Cali | - | Independiente Medellín | 1:2 | ||||
15. Round | 28/03/2021 | Independiente Medellín | - | Atlético Nacional | 0:0 | ||||
17. Round | 07/04/2021 | Deportivo Pereira | - | Independiente Medellín | 1:0 | ||||
18. Round | 10/04/2021 | Independiente Medellín | - | Alianza Petrolera | 2:2 |