| 2. Round | 27/07/2021 | Deportivo Pereira | - | Alianza Petrolera | 0:2 | ||||
| 3. Round | 31/07/2021 | Deportes Tolima | - | Alianza Petrolera | 1:1 | ||||
| 4. Round | 09/08/2021 | Alianza Petrolera | - | Deportivo Pasto | 2:0 | ||||
| 5. Round | 14/08/2021 | Envigado FC | - | Alianza Petrolera | 2:1 | ||||
| 6. Round | 23/08/2021 | Alianza Petrolera | - | Deportivo Cali | 2:3 |  |
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| 12. Round | 04/10/2021 | Alianza Petrolera | - | Jaguares de Córdoba | 1:1 | |
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| 14. Round | 17/10/2021 | Alianza Petrolera | - | Atlético Bucaramanga | 2:0 | ||||
| 15. Round | 23/10/2021 | Deportes Quindío | - | Alianza Petrolera | 1:0 | ||||
| 16. Round | 27/10/2021 | Alianza Petrolera | - | Independiente Medellín | 3:0 | ||||
| 18. Round | 06/11/2021 | Alianza Petrolera | - | Atlético Huila | 1:0 |
Colombia
Panama