| 1. Round | 19/09/2020 | Inter [Youth] | - | Sampdoria [Youth] | 3:0 | ||||
| 2. Round | 27/09/2020 | Sampdoria [Youth] | - | Lazio Roma [Youth] | 1:1 |  |
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| 3. Round | 03/10/2020 | Genoa CFC [Youth] | - | Sampdoria [Youth] | 1:0 | ||||
| 8. Round | 30/01/2021 | Sampdoria [Youth] | - | Bologna FC [Youth] | 2:0 | ||||
| 5. Round | 07/02/2021 | Juventus [Youth] | - | Sampdoria [Youth] | 1:4 | ||||
| 9. Round | 10/02/2021 | Atalanta [Youth] | - | Sampdoria [Youth] | 3:1 | ||||
| 6. Round | 13/02/2021 | Sampdoria [Youth] | - | SPAL 2013 Ferrara [Youth] | 2:1 | ||||
| 10. Round | 17/02/2021 | Sassuolo Calcio [Youth] | - | Sampdoria [Youth] | 0:0 | |
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| 11. Round | 21/02/2021 | Sampdoria [Youth] | - | AC Milan [Youth] | 1:0 |  |
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| 12. Round | 28/02/2021 | Sampdoria [Youth] | - | AS Roma [Youth] | 1:1 | ||||
| 19. Round | 18/04/2021 | Empoli FC [Youth] | - | Sampdoria [Youth] | 2:2 | ||||
| 20. Round | 26/04/2021 | Sampdoria [Youth] | - | Juventus [Youth] | 1:2 | |
Belgium