| 1. Round | 19/02/2012 | Nacional | - | River Plate | 3:2 | ||||
| 2. Round | 25/02/2012 | River Plate | - | Liverpool | 1:3 | ||||
| 3. Round | 04/03/2012 | Rentistas | - | River Plate | 0:2 | ||||
| 4. Round | 11/03/2012 | River Plate | - | Montevideo Wanderers | 2:2 |  |
 |
||
| 5. Round | 24/03/2012 | Rampla Juniors | - | River Plate | 2:1 | ||||
| 6. Round | 01/04/2012 | River Plate | - | Cerrito | 2:2 | ||||
| 8. Round | 15/04/2012 | River Plate | - | CA Cerro | 3:3 | ||||
| 9. Round | 22/04/2012 | Cerro Largo | - | River Plate | 0:3 | |
|||
| 10. Round | 28/04/2012 | River Plate | - | Fénix | 2:1 | ||||
| 7. Round | 02/05/2012 | Peñarol | - | River Plate | 1:0 | ||||
| 11. Round | 06/05/2012 | Bella Vista | - | River Plate | 0:1 | |
|||
| 12. Round | 13/05/2012 | River Plate | - | Danubio | 1:1 | ||||
| 13. Round | 19/05/2012 | River Plate | - | El Tanque Sisley | 4:0 | ||||
| 14. Round | 28/05/2012 | Racing | - | River Plate | 4:2 | ||||
| 15. Round | 03/06/2012 | River Plate | - | Defensor Sporting | 2:1 |
Brazil