| 1. Round | 17/01/2021 | Deportes Quindío | - | Valledupar FC | 1:2 | ||||
| 2. Round | 23/01/2021 | Valledupar FC | - | Orsomarso SC | 3:4 | ||||
| 3. Round | 31/01/2021 | Boca Juniors de Cali | - | Valledupar FC | 1:2 |  |
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| 4. Round | 08/02/2021 | Valledupar FC | - | Real Cartagena | 2:0 | ||||
| 5. Round | 11/02/2021 | Real Santander | - | Valledupar FC | 0:1 | |
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| 7. Round | 23/02/2021 | Fortaleza FC | - | Valledupar FC | 3:2 | ||||
| 9. Round | 03/03/2021 | Atlético Huila | - | Valledupar FC | 3:1 | ||||
| 14. Round | 05/04/2021 | Llaneros FC | - | Valledupar FC | 2:1 |
Colombia