| 1. Round | 19/07/2022 | AD Guanacasteca | - | CS Herediano | 0:2 | ||||
| 4. Round | 08/08/2022 | Santos de Guápiles | - | AD Guanacasteca | 0:1 |  |
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| 5. Round | 11/08/2022 | AD Guanacasteca | - | Guadalupe | 1:2 | ||||
| 6. Round | 15/08/2022 | Guadalupe | - | AD Guanacasteca | 1:0 | ||||
| 7. Round | 21/08/2022 | AD Guanacasteca | - | LD Alajuelense | 1:2 | ||||
| 8. Round | 28/08/2022 | Sporting FC | - | AD Guanacasteca | 4:1 | ||||
| 9. Round | 31/08/2022 | CS Herediano | - | AD Guanacasteca | 3:0 | ||||
| 10. Round | 04/09/2022 | AD Guanacasteca | - | Santos de Guápiles | 1:0 | ||||
| 12. Round | 17/09/2022 | AD Guanacasteca | - | Municipal Pérez Zeledón | 0:2 | ||||
| 15. Round | 29/09/2022 | Deportivo Saprissa | - | AD Guanacasteca | 1:0 | ||||
| 16. Round | 02/10/2022 | AD Guanacasteca | - | CS Cartaginés | 1:1 | |
Nicaragua