| 3. Round | 16/08/2021 | Managua FC | - | Real Estelí FC | 3:0 | ||||
| 4. Round | 22/08/2021 | H&H Export Sébaco | - | Managua FC | 0:0 | ||||
| 5. Round | 30/08/2021 | Managua FC | - | Diriangén FC | 1:2 | ||||
| 7. Round | 13/09/2021 | UNAN Managua | - | Managua FC | 2:3 |  |
|||
| 8. Round | 20/09/2021 | Managua FC | - | Real Madriz | 1:1 | ||||
| 6. Round | 23/09/2021 | Managua FC | - | Club Deportivo Ocotal | 3:1 | |
|||
| 9. Round | 27/09/2021 | CD Walter Ferretti | - | Managua FC | 0:0 | |
|||
| 10. Round | 02/10/2021 | Juventus Managua | - | Managua FC | 1:3 | |
|||
| 12. Round | 17/10/2021 | Real Estelí FC | - | Managua FC | 1:0 | ||||
| 13. Round | 21/10/2021 | Managua FC | - | H&H Export Sébaco | 1:2 | |
|||
| 15. Round | 31/10/2021 | Managua FC | - | UNAN Managua | 3:0 | ||||
| 16. Round | 05/11/2021 | Club Deportivo Ocotal | - | Managua FC | 1:0 | ||||
| 17. Round | 18/11/2021 | Real Madriz | - | Managua FC | 1:3 | |
|||
| 18. Round | 22/11/2021 | Managua FC | - | CD Walter Ferretti | 3:1 |
Nicaragua