| 1. Round | 21/08/2021 | Paphos FC | - | APOEL Nikosia | 4:0 | ||||
| 2. Round | 13/09/2021 | AEL Limassol | - | Paphos FC | 4:0 | ||||
| 3. Round | 18/09/2021 | Paphos FC | - | AEK Larnaca | 1:1 | ||||
| 4. Round | 26/09/2021 | Omonia Nikosia | - | Paphos FC | 1:1 | ||||
| 7. Round | 23/10/2021 | Apollon Limassol | - | Paphos FC | 2:0 | ||||
| 8. Round | 01/11/2021 | Paphos FC | - | PAEEK | 2:0 | ||||
| 9. Round | 07/11/2021 | Anorthosis Famagusta | - | Paphos FC | 1:0 |  |
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| 10. Round | 20/11/2021 | Paphos FC | - | Ethnikos Achna | 3:0 | |
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| 11. Round | 27/11/2021 | Aris Limassol | - | Paphos FC | 0:0 | ||||
| 12. Round | 05/12/2021 | APOEL Nikosia | - | Paphos FC | 1:1 | ||||
| 13. Round | 10/12/2021 | Paphos FC | - | AEL Limassol | 1:0 | ||||
| 17. Round | 15/01/2022 | Olympiakos Nikosia | - | Paphos FC | 1:2 | ||||
| 18. Round | 22/01/2022 | Paphos FC | - | Apollon Limassol | 0:1 | ||||
| 19. Round | 28/01/2022 | PAEEK | - | Paphos FC | 0:2 | |
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| 20. Round | 06/02/2022 | Paphos FC | - | Anorthosis Famagusta | 1:1 | |
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| 16. Round | 18/02/2022 | Doxa Katokopias | - | Paphos FC | 1:1 | |
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| 22. Round | 25/02/2022 | Paphos FC | - | Aris Limassol | 1:1 | |
England
Jamaica 
