| 1. Round | 07/08/2010 | Southampton FC | - | Plymouth Argyle | 0:1 | ||||
| 3. Round | 21/08/2010 | Southampton FC | - | Leyton Orient | 1:1 | ||||
| 4. Round | 28/08/2010 | Bristol Rovers | - | Southampton FC | 0:4 | ||||
| 5. Round | 04/09/2010 | Southampton FC | - | Rochdale AFC | 0:2 | ||||
| 6. Round | 11/09/2010 | Swindon Town | - | Southampton FC | 1:0 | ||||
| 2. Round | 15/09/2010 | Milton Keynes Dons | - | Southampton FC | 2:0 | ||||
| 7. Round | 18/09/2010 | Southampton FC | - | Colchester United | 0:0 | ||||
| 8. Round | 25/09/2010 | Sheffield Wednesday | - | Southampton FC | 0:1 | ||||
| 9. Round | 28/09/2010 | Yeovil Town | - | Southampton FC | 1:1 | ||||
| 10. Round | 02/10/2010 | Southampton FC | - | AFC Bournemouth | 2:0 | ||||
| 11. Round | 09/10/2010 | Southampton FC | - | Tranmere Rovers | 2:0 | ||||
| 12. Round | 16/10/2010 | Huddersfield Town | - | Southampton FC | 2:0 | ||||
| 13. Round | 23/10/2010 | Southampton FC | - | Oldham Athletic | 2:1 | ||||
| 14. Round | 30/10/2010 | Notts County | - | Southampton FC | 1:3 | ||||
| 27. Round | 15/01/2011 | Southampton FC | - | Notts County | 0:0 |
England
Jamaica 
