| 1. Round | 11/07/2022 | Diriangén FC | - | Matagalpa FC | 2:0 |  |
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| 2. Round | 17/07/2022 | Matagalpa FC | - | ART Municipal Jalapa | 0:0 | ||||
| 3. Round | 24/07/2022 | Juventus Managua | - | Matagalpa FC | 3:2 | ||||
| 5. Round | 07/08/2022 | Club Deportivo Ocotal | - | Matagalpa FC | 1:1 | ||||
| 6. Round | 11/08/2022 | Matagalpa FC | - | CD Walter Ferretti | 1:0 | ||||
| 9. Round | 28/08/2022 | Matagalpa FC | - | Real Estelí FC | 0:3 | ||||
| 11. Round | 11/09/2022 | ART Municipal Jalapa | - | Matagalpa FC | 2:1 |  |
Nicaragua