| 2. Round | 26/07/2021 | Cerro Porteño | - | Libertad | 1:1 |  |
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| 3. Round | 01/08/2021 | Libertad | - | Sol de América | 1:1 | |
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| 4. Round | 07/08/2021 | Club Nacional | - | Libertad | 1:0 | ||||
| 5. Round | 16/08/2021 | Libertad | - | 12 de Octubre de Itauguá | 3:3 | ||||
| 6. Round | 24/08/2021 | Guaraní | - | Libertad | 2:2 | ||||
| 10. Round | 27/09/2021 | Guaireña FC | - | Libertad | 2:1 | ||||
| 12. Round | 17/10/2021 | Sol de América | - | Libertad | 0:4 | ||||
| 13. Round | 25/10/2021 | Libertad | - | Club Nacional | 1:2 | ||||
| 14. Round | 30/10/2021 | 12 de Octubre de Itauguá | - | Libertad | 0:1 |  |
Paraguay
Argentina