| 1. Round | 01/08/2021 | FAS | - | Santa Tecla FC | 3:1 | ||||
| 3. Round | 04/08/2021 | FAS | - | Jocoro FC | 4:1 |  |
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| 2. Round | 08/08/2021 | CD Águila | - | FAS | 1:1 | ||||
| 4. Round | 15/08/2021 | Municipal Limeño | - | FAS | 0:3 |  |
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| 5. Round | 22/08/2021 | FAS | - | Platense Zacatecoluca | 0:1 | ||||
| 7. Round | 29/08/2021 | FAS | - | Luis Ángel Firpo | 3:1 | ||||
| 8. Round | 12/09/2021 | Once Municipal | - | FAS | 1:3 | ||||
| 9. Round | 16/09/2021 | AD Chalatenango | - | FAS | 1:2 | ||||
| 12. Round | 03/10/2021 | Santa Tecla FC | - | FAS | 1:0 | ||||
| 13. Round | 18/10/2021 | FAS | - | CD Águila | 0:1 | ||||
| 18. Round | 07/11/2021 | Luis Ángel Firpo | - | FAS | 2:0 | |
El Salvador