| 1. Round | 17/07/2021 | Universidad San Martín | - | Mannucci | 0:2 |  |
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| 2. Round | 23/07/2021 | Mannucci | - | Deportivo Municipal | 1:2 | ||||
| 3. Round | 31/07/2021 | Universitario de Deportes | - | Mannucci | 1:3 | ||||
| 5. Round | 07/08/2021 | Universidad Cesar Vallejo | - | Mannucci | 0:1 | ||||
| 6. Round | 13/08/2021 | Mannucci | - | Deportivo Binacional | 3:1 | ||||
| 7. Round | 17/08/2021 | Cusco FC | - | Mannucci | 2:3 | ||||
| 8. Round | 21/08/2021 | Mannucci | - | FBC Melgar | 1:2 | ||||
| 9. Round | 28/08/2021 | Alianza Atlético | - | Mannucci | 2:0 | ||||
| 14. Round | 01/10/2021 | Ayacucho FC | - | Mannucci | 3:2 | ||||
| 15. Round | 16/10/2021 | Mannucci | - | Alianza Lima | 0:1 | ||||
| 16. Round | 22/10/2021 | Sport Boys | - | Mannucci | 3:3 |  |
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| 17. Round | 30/10/2021 | Mannucci | - | Academia Cantolao | 1:0 |
Peru