| 1. Round | 06/02/2022 | FBC Melgar | - | Mannucci | 1:0 | ||||
| 4. Round | 26/02/2022 | Mannucci | - | Sport Huancayo | 0:1 | ||||
| 5. Round | 06/03/2022 | Academia Cantolao | - | Mannucci | 3:2 | ||||
| 6. Round | 12/03/2022 | Mannucci | - | Carlos Stein | 1:0 | ||||
| 7. Round | 22/03/2022 | Universidad San Martín | - | Mannucci | 1:3 |  |
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| 8. Round | 04/04/2022 | Mannucci | - | Universidad Cesar Vallejo | 0:0 | ||||
| 9. Round | 09/04/2022 | Deportivo Municipal | - | Mannucci | 1:0 | ||||
| 10. Round | 16/04/2022 | Mannucci | - | Cienciano | 0:2 | ||||
| 11. Round | 24/04/2022 | Deportivo Binacional | - | Mannucci | 2:1 | ||||
| 12. Round | 01/05/2022 | Mannucci | - | AD Tarma | 1:1 | ||||
| 13. Round | 08/05/2022 | Ayacucho FC | - | Mannucci | 2:2 | ||||
| 14. Round | 15/05/2022 | Mannucci | - | Universitario de Deportes | 0:0 | ||||
| 15. Round | 22/05/2022 | Sport Boys | - | Mannucci | 1:4 | |
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| 16. Round | 29/05/2022 | Mannucci | - | Atlético Grau | 1:0 | ||||
| 17. Round | 19/06/2022 | Alianza Atlético | - | Mannucci | 0:0 |  |
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| 18. Round | 24/06/2022 | Universidad Técnica | - | Mannucci | 1:2 | |
Peru