| 2. Round | 27/07/2013 | Santos Laguna | - | Cruz Azul | 3:2 | ||||
| 3. Round | 01/08/2013 | Puebla FC | - | Santos Laguna | 1:1 | ||||
| 4. Round | 04/08/2013 | Santos Laguna | - | Gallos Blancos | 2:0 | ||||
| 5. Round | 11/08/2013 | Deportivo Toluca | - | Santos Laguna | 2:2 |  |
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| 6. Round | 17/08/2013 | Santos Laguna | - | UANL Tigres | 3:0 | ||||
| 7. Round | 24/08/2013 | Club Tijuana | - | Santos Laguna | 1:1 | ||||
| 8. Round | 31/08/2013 | Santos Laguna | - | Club León | 0:2 | ||||
| 9. Round | 08/09/2013 | Atlas Guadalajara | - | Santos Laguna | 2:2 | |
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| 15. Round | 27/10/2013 | Atlante | - | Santos Laguna | 1:3 | ||||
| 1. Round | 31/10/2013 | Deportivo Guadalajara | - | Santos Laguna | 0:2 | ||||
| 16. Round | 03/11/2013 | Chiapas FC | - | Santos Laguna | 2:1 | |
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| 17. Round | 09/11/2013 | Santos Laguna | - | CD Veracruz | 2:2 | |
Mexico