| 1. Round | 10/01/2015 | Santos Laguna | - | CD Veracruz | 1:2 | ||||
| 2. Round | 17/01/2015 | Cruz Azul | - | Santos Laguna | 1:0 | ||||
| 3. Round | 24/01/2015 | Santos Laguna | - | CF Monterrey | 4:1 | ||||
| 4. Round | 31/01/2015 | Gallos Blancos | - | Santos Laguna | 0:1 | ||||
| 5. Round | 07/02/2015 | Santos Laguna | - | Deportivo Guadalajara | 1:0 | ||||
| 6. Round | 15/02/2015 | Deportivo Toluca | - | Santos Laguna | 2:2 | ||||
| 7. Round | 21/02/2015 | Santos Laguna | - | Atlas Guadalajara | 0:1 | ||||
| 8. Round | 01/03/2015 | Club León | - | Santos Laguna | 2:1 | ||||
| 9. Round | 08/03/2015 | Santos Laguna | - | Club Tijuana | 1:1 | ||||
| 10. Round | 14/03/2015 | CF América | - | Santos Laguna | 1:0 | ||||
| 14. Round | 19/04/2015 | Pumas UNAM | - | Santos Laguna | 1:0 | ||||
| 15. Round | 25/04/2015 | Santos Laguna | - | Leones Negros | 1:0 | ||||
| 16. Round | 03/05/2015 | CF Pachuca | - | Santos Laguna | 2:3 | ||||
| 17. Round | 10/05/2015 | Santos Laguna | - | Puebla FC | 2:2 |  |
Mexico