| 1. Round | 03/02/2025 | Leones FC | - | Boca Juniors de Cali | 1:1 | ||||
| 4. Round | 24/02/2025 | Barranquilla FC | - | Leones FC | 2:3 | ||||
| 7. Round | 17/03/2025 | Real Santander | - | Leones FC | 1:0 | ||||
| 8. Round | 25/03/2025 | Leones FC | - | Real Soacha Cundinamarca | 3:1 | ||||
| 9. Round | 28/03/2025 | Jaguares de Córdoba | - | Leones FC | 2:0 | ||||
| 10. Round | 06/04/2025 | Leones FC | - | Deportes Quindío | 4:1 | ||||
| 11. Round | 12/04/2025 | Patriotas FC | - | Leones FC | 3:1 | ||||
| 15. Round | 10/05/2025 | Atlético FC | - | Leones FC | 0:0 | ||||
| 16. Round | 17/05/2025 | Leones FC | - | Bogotá FC | 3:0 |
Colombia