| 3. Round | 24/07/2022 | Club Deportivo Ocotal | - | Diriangén FC | 1:1 | ||||
| 5. Round | 07/08/2022 | Club Deportivo Ocotal | - | Matagalpa FC | 1:1 | ||||
| 6. Round | 11/08/2022 | Club Deportivo Ocotal | - | H&H Export Sébaco | 2:1 | ||||
| 7. Round | 14/08/2022 | ART Municipal Jalapa | - | Club Deportivo Ocotal | 0:3 dec. |  |
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| 8. Round | 21/08/2022 | CD Walter Ferretti | - | Club Deportivo Ocotal | 1:3 | |
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| 9. Round | 28/08/2022 | Club Deportivo Ocotal | - | Juventus Managua | 2:2 | |
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| 11. Round | 11/09/2022 | Real Estelí FC | - | Club Deportivo Ocotal | 5:0 | ||||
| 17. Round | 27/11/2022 | Club Deportivo Ocotal | - | CD Walter Ferretti | 1:1 | ||||
| 18. Round | 30/11/2022 | Juventus Managua | - | Club Deportivo Ocotal | 9:0 | |
Nicaragua