| 14. Round | 14/04/2022 | Municipal Pérez Zeledón | - | AD San Carlos | 1:0 | ||||
| 15. Round | 20/04/2022 | AD San Carlos | - | Guadalupe | 2:1 | ||||
| 16. Round | 24/04/2022 | CS Herediano | - | AD San Carlos | 1:1 | ||||
| 17. Round | 27/04/2022 | AD Guanacasteca | - | AD San Carlos | 2:3 | ||||
| 18. Round | 01/05/2022 | AD San Carlos | - | Municipal Grecia | 2:2 | ||||
| 21. Round | 13/05/2022 | LD Alajuelense | - | AD San Carlos | 1:0 |  |
Costa Rica