| 2. Round | 25/01/2021 | Atlético Huila | - | Bogotá FC | 4:0 |  |
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| 3. Round | 30/01/2021 | Fortaleza FC | - | Atlético Huila | 3:4 | ||||
| 4. Round | 05/02/2021 | Atlético Huila | - | Leones FC | 1:1 | ||||
| 5. Round | 11/02/2021 | Atlético Huila | - | Tigres FC | 1:0 | ||||
| 6. Round | 14/02/2021 | Cortuluá | - | Atlético Huila | 0:0 | ||||
| 1. Round | 17/02/2021 | Real Santander | - | Atlético Huila | 2:2 | ||||
| 7. Round | 22/02/2021 | Atlético Huila | - | Atlético FC | 0:2 | ||||
| 8. Round | 27/02/2021 | Barranquilla FC | - | Atlético Huila | 0:0 |  |
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| 9. Round | 03/03/2021 | Atlético Huila | - | Valledupar FC | 3:1 | ||||
| 10. Round | 06/03/2021 | Llaneros FC | - | Atlético Huila | 0:2 | |
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| 11. Round | 14/03/2021 | Atlético Huila | - | Unión Magdalena | 1:0 | |
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| 12. Round | 22/03/2021 | Deportes Quindío | - | Atlético Huila | 0:0 | ||||
| 13. Round | 27/03/2021 | Atlético Huila | - | Orsomarso SC | 3:2 | |
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| 14. Round | 05/04/2021 | Boca Juniors de Cali | - | Atlético Huila | 2:2 | ||||
| 15. Round | 09/04/2021 | Atlético Huila | - | Real Cartagena | 4:1 |
Colombia