| 2. Round | 10/08/2021 | Chavelines Juniors | - | Santos FC | 3:0 |  |
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| 3. Round | 13/08/2021 | Santos FC | - | Deportivo Coopsol | 1:4 | ||||
| 4. Round | 20/08/2021 | Juan Aurich | - | Santos FC | 2:2 | ||||
| 5. Round | 26/08/2021 | Santos FC | - | Pirata | 2:0 | ||||
| 7. Round | 07/09/2021 | Santos FC | - | Atlético Grau | 0:0 | ||||
| 9. Round | 16/09/2021 | Llacuabamba | - | Santos FC | 0:2 | ||||
| 10. Round | 21/09/2021 | Santos FC | - | Los Chankas | 0:1 | ||||
| 11. Round | 30/09/2021 | Carlos Stein | - | Santos FC | 3:0 |
Colombia