2. Round | 10/08/2021 | UNAN Managua | - | H&H Export Sébaco | 0:2 | ||||
3. Round | 15/08/2021 | H&H Export Sébaco | - | Club Deportivo Ocotal | 0:1 | ||||
4. Round | 22/08/2021 | H&H Export Sébaco | - | Managua FC | 0:0 | ||||
5. Round | 29/08/2021 | Juventus Managua | - | H&H Export Sébaco | 1:0 | ||||
6. Round | 03/09/2021 | ART Municipal Jalapa | - | H&H Export Sébaco | 0:2 | ||||
8. Round | 19/09/2021 | Diriangén FC | - | H&H Export Sébaco | 1:0 | ||||
11. Round | 10/10/2021 | H&H Export Sébaco | - | UNAN Managua | 1:1 | ||||
13. Round | 21/10/2021 | Managua FC | - | H&H Export Sébaco | 1:2 | ||||
17. Round | 17/11/2021 | H&H Export Sébaco | - | Diriangén FC | 1:1 | ||||
18. Round | 20/11/2021 | H&H Export Sébaco | - | Real Madriz | 2:3 |