3. Round | 06/02/2022 | Real Sociedad | - | Lobos UPNFM | 2:2 | ||||
6. Round | 20/02/2022 | Lobos UPNFM | - | Motagua | 0:0 | ||||
9. Round | 06/03/2022 | Marathón | - | Lobos UPNFM | 4:1 | ||||
10. Round | 13/03/2022 | Lobos UPNFM | - | Real Sociedad | 1:0 | ||||
11. Round | 19/03/2022 | Lobos UPNFM | - | Honduras Progreso | 2:2 | ||||
12. Round | 03/04/2022 | Platense | - | Lobos UPNFM | 1:0 | ||||
14. Round | 10/04/2022 | Motagua | - | Lobos UPNFM | 2:0 | ||||
15. Round | 14/04/2022 | Lobos UPNFM | - | Real España | 0:2 | ||||
16. Round | 21/04/2022 | Vida | - | Lobos UPNFM | 4:2 |