| Group B | 21/05/2022 | Envigado FC | - | Deportes Tolima | 1:4 | ||||
| Group B | 02/06/2022 | Deportes Tolima | - | Independiente Medellín | 0:0 | ||||
| Group B | 06/06/2022 | Deportes Tolima | - | La Equidad | 1:0 |  |
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| Group B | 10/06/2022 | La Equidad | - | Deportes Tolima | 1:0 | ||||
| Group B | 12/06/2022 | Independiente Medellín | - | Deportes Tolima | 0:1 |  |
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| Group B | 17/06/2022 | Deportes Tolima | - | Envigado FC | 1:0 | ||||
| Final | 27/06/2022 | Deportes Tolima | - | Atlético Nacional | 2:1 |
Colombia