| 1. Round | 25/07/2015 | KV Oostende | - | KV Mechelen | 3:1 | ||||
| 2. Round | 01/08/2015 | Club Brugge KV | - | KV Mechelen | 3:0 |  |
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| 3. Round | 08/08/2015 | KV Mechelen | - | Royal Mouscron-Péruwelz | 3:1 | ||||
| 4. Round | 15/08/2015 | Sporting Lokeren | - | KV Mechelen | 2:0 | |
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| 5. Round | 22/08/2015 | KV Mechelen | - | Oud-Heverlee Leuven | 2:1 | ||||
| 6. Round | 29/08/2015 | KAA Gent | - | KV Mechelen | 2:2 | ||||
| 7. Round | 12/09/2015 | KV Mechelen | - | KVC Westerlo | 2:2 | ||||
| 8. Round | 18/09/2015 | KRC Genk | - | KV Mechelen | 3:1 | ||||
| 9. Round | 26/09/2015 | KV Mechelen | - | Sporting Charleroi | 0:1 | ||||
| 15. Round | 07/11/2015 | KV Kortrijk | - | KV Mechelen | 1:0 | ||||
| 16. Round | 22/11/2015 | KV Mechelen | - | KV Oostende | 2:1 | ||||
| 17. Round | 29/11/2015 | KV Mechelen | - | Club Brugge KV | 1:4 |  |
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| 18. Round | 05/12/2015 | Royal Mouscron-Péruwelz | - | KV Mechelen | 2:3 | ||||
| 19. Round | 12/12/2015 | KV Mechelen | - | Sporting Lokeren | 1:1 | |
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| 20. Round | 19/12/2015 | Oud-Heverlee Leuven | - | KV Mechelen | 3:1 | ||||
| 21. Round | 26/12/2015 | KV Mechelen | - | KAA Gent | 2:0 | ||||
| 22. Round | 16/01/2016 | KVC Westerlo | - | KV Mechelen | 3:2 | ||||
| 24. Round | 30/01/2016 | Sporting Charleroi | - | KV Mechelen | 3:2 |
Belgium