| 22. Round | 17/01/2022 | Jong Ajax | - | FC Den Bosch | 2:1 | ||||
| 23. Round | 21/01/2022 | FC Den Bosch | - | FC Eindhoven | 0:2 | ||||
| 24. Round | 28/01/2022 | TOP Oss | - | FC Den Bosch | 2:1 | ||||
| 25. Round | 06/02/2022 | FC Den Bosch | - | ADO Den Haag | 0:1 | ||||
| 26. Round | 13/02/2022 | NAC Breda | - | FC Den Bosch | 2:0 | ||||
| 28. Round | 25/02/2022 | De Graafschap | - | FC Den Bosch | 0:0 | ||||
| 29. Round | 04/03/2022 | SBV Excelsior | - | FC Den Bosch | 4:0 | ||||
| 30. Round | 11/03/2022 | FC Den Bosch | - | MVV | 3:1 | ||||
| 27. Round | 14/03/2022 | FC Den Bosch | - | Jong PSV | 3:2 | ||||
| 32. Round | 26/03/2022 | FC Den Bosch | - | VVV-Venlo | 0:0 | ||||
| 33. Round | 01/04/2022 | Telstar | - | FC Den Bosch | 1:2 | ||||
| 34. Round | 08/04/2022 | FC Den Bosch | - | FC Dordrecht | 3:0 | ||||
| 35. Round | 18/04/2022 | FC Utrecht (J) | - | FC Den Bosch | 0:1 |  |
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| 36. Round | 22/04/2022 | FC Den Bosch | - | FC Volendam | 1:2 |  |
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| 37. Round | 29/04/2022 | FC Den Bosch | - | Roda JC Kerkrade | 1:0 | ||||
| 38. Round | 06/05/2022 | Helmond Sport | - | FC Den Bosch | 1:1 |
Netherlands