| 1. Round | 28/08/2021 | Fermana FC | - | Viterbese | 3:3 | ||||
| 3. Round | 12/09/2021 | Fermana FC | - | Aquila Montevarchi | 0:1 | ||||
| 6. Round | 28/09/2021 | Fermana FC | - | US Grosseto FC | 2:0 | ||||
| 8. Round | 09/10/2021 | Fermana FC | - | ACN Siena 1904 | 1:1 | ||||
| 9. Round | 16/10/2021 | Delfino Pescara | - | Fermana FC | 2:1 | ||||
| 10. Round | 19/10/2021 | Fermana FC | - | Lucchese | 0:0 |  |
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| 12. Round | 31/10/2021 | Fermana FC | - | US Pontedera | 1:0 | ||||
| 18. Round | 12/12/2021 | Olbia Calcio | - | Fermana FC | 0:0 |  |
France