| 2. Round | 10/08/2021 | UNAN Managua | - | H&H Export Sébaco | 0:2 | ||||
| 3. Round | 15/08/2021 | H&H Export Sébaco | - | Club Deportivo Ocotal | 0:1 | ||||
| 4. Round | 22/08/2021 | H&H Export Sébaco | - | Managua FC | 0:0 | ||||
| 5. Round | 29/08/2021 | Juventus Managua | - | H&H Export Sébaco | 1:0 | ||||
| 6. Round | 03/09/2021 | ART Municipal Jalapa | - | H&H Export Sébaco | 0:2 |  |
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| 7. Round | 12/09/2021 | H&H Export Sébaco | - | CD Walter Ferretti | 4:8 | ||||
| 9. Round | 26/09/2021 | Real Madriz | - | H&H Export Sébaco | 3:3 | ||||
| 11. Round | 10/10/2021 | H&H Export Sébaco | - | UNAN Managua | 1:1 | ||||
| 12. Round | 16/10/2021 | Club Deportivo Ocotal | - | H&H Export Sébaco | 1:1 | ||||
| 15. Round | 31/10/2021 | CD Walter Ferretti | - | H&H Export Sébaco | 2:1 | ||||
| 16. Round | 04/11/2021 | H&H Export Sébaco | - | ART Municipal Jalapa | 3:0 | ||||
| 17. Round | 17/11/2021 | H&H Export Sébaco | - | Diriangén FC | 1:1 |
Nicaragua