| 1. Round | 13/08/2000 | K.S.C. Eendracht Aalst | - | Lierse SK (old) | 1:3 | ||||
| 2. Round | 19/08/2000 | Sint-Truidense VV | - | Lierse SK (old) | 0:1 | ||||
| 3. Round | 27/08/2000 | KVC Westerlo | - | Lierse SK (old) | 1:0 | ||||
| 4. Round | 06/09/2000 | Lierse SK (old) | - | KSK Beveren | 3:0 | ||||
| 5. Round | 09/09/2000 | RSC Charleroi | - | Lierse SK (old) | 2:0 | ||||
| 6. Round | 16/09/2000 | Lierse SK (old) | - | Royal Antwerp FC | 4:1 | ||||
| 15. Round | 02/12/2000 | Lierse SK (old) | - | Germinal Beerschot | 1:1 | ||||
| 26. Round | 17/03/2001 | KRC Genk | - | Lierse SK (old) | 2:0 | ||||
| 30. Round | 21/04/2001 | Standard Liège | - | Lierse SK (old) | 3:2 | ||||
| 31. Round | 28/04/2001 | Lierse SK (old) | - | RAA La Louviére | 1:2 | ||||
| 32. Round | 05/05/2001 | Germinal Beerschot | - | Lierse SK (old) | 6:0 | ||||
| 33. Round | 12/05/2001 | Lierse SK (old) | - | Club Brugge KV | 0:2 | ||||
| 34. Round | 20/05/2001 | KV Mechelen | - | Lierse SK (old) | 1:1 |  |
Belgium