| 5. Round | 07/08/2022 | H&H Export Sébaco | - | UNAN Managua | 5:0 | ||||
| 6. Round | 12/08/2022 | UNAN Managua | - | Juventus Managua | 2:1 | ||||
| 7. Round | 14/08/2022 | UNAN Managua | - | Matagalpa FC | 3:0 | ||||
| 8. Round | 21/08/2022 | Real Estelí FC | - | UNAN Managua | 1:0 |  |
|||
| 4. Round | 25/08/2022 | UNAN Managua | - | Club Deportivo Ocotal | 2:0 | |
|||
| 9. Round | 29/08/2022 | Managua FC | - | UNAN Managua | 2:1 | ||||
| 13. Round | 23/10/2022 | Club Deportivo Ocotal | - | UNAN Managua | 2:3 | ||||
| 14. Round | 27/10/2022 | UNAN Managua | - | H&H Export Sébaco | 0:0 | ||||
| 15. Round | 31/10/2022 | Juventus Managua | - | UNAN Managua | 2:1 | ||||
| 17. Round | 28/11/2022 | UNAN Managua | - | Real Estelí FC | 1:4 |
Colombia