| 1. Round | 06/02/2022 | San Francisco FC | - | Veraguas United | 0:1 | ||||
| 2. Round | 12/02/2022 | San Francisco FC | - | Independiente de La Chorrera | 2:0 | ||||
| 3. Round | 20/02/2022 | Atlético Chiriquí | - | San Francisco FC | 2:1 | ||||
| 4. Round | 26/02/2022 | San Francisco FC | - | UD Universitario | 0:1 | ||||
| 5. Round | 05/03/2022 | Herrera FC | - | San Francisco FC | 0:0 | ||||
| 6. Round | 09/03/2022 | San Francisco FC | - | Árabe Unido | 0:0 | ||||
| 7. Round | 13/03/2022 | Alianza | - | San Francisco FC | 2:1 | ||||
| 8. Round | 20/03/2022 | Tauro FC | - | San Francisco FC | 1:0 |  |
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| 9. Round | 26/03/2022 | San Francisco FC | - | Sporting San Miguelito | 0:1 | ||||
| 10. Round | 02/04/2022 | San Francisco FC | - | Plaza Amador | 2:2 | ||||
| 11. Round | 09/04/2022 | Potros del Este | - | San Francisco FC | 0:0 | |
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| 14. Round | 27/04/2022 | San Francisco FC | - | Atlético Chiriquí | 2:2 | ||||
| 15. Round | 30/04/2022 | UD Universitario | - | San Francisco FC | 0:1 | ||||
| 12. Round | 05/05/2022 | Veraguas United | - | San Francisco FC | 0:2 | ||||
| 16. Round | 08/05/2022 | San Francisco FC | - | Herrera FC | 3:1 |
Panama