2. Round | 02/08/2021 | Santos Laguna | - | Cruz Azul | 1:1 | ||||
3. Round | 08/08/2021 | UANL Tigres | - | Santos Laguna | 1:1 | ||||
4. Round | 16/08/2021 | Santos Laguna | - | Deportivo Guadalajara | 0:0 | ||||
8. Round | 11/09/2021 | Club Tijuana | - | Santos Laguna | 2:1 | ||||
15. Round | 25/10/2021 | Santos Laguna | - | Deportivo Toluca | 2:2 | ||||
16. Round | 30/10/2021 | Gallos Blancos | - | Santos Laguna | 2:3 | ||||
11. Round | 05/11/2021 | Pumas UNAM | - | Santos Laguna | 0:3 |