| 1. Round | 16/01/2021 | Orsomarso SC | - | Barranquilla FC | 2:2 | ||||
| 3. Round | 01/02/2021 | Real Cartagena | - | Barranquilla FC | 1:0 | ||||
| 4. Round | 06/02/2021 | Barranquilla FC | - | Real Santander | 1:0 | ||||
| 6. Round | 15/02/2021 | Barranquilla FC | - | Fortaleza FC | 1:2 | ||||
| 7. Round | 22/02/2021 | Leones FC | - | Barranquilla FC | 2:1 | ||||
| 12. Round | 21/03/2021 | Valledupar FC | - | Barranquilla FC | 2:0 | ||||
| 14. Round | 03/04/2021 | Unión Magdalena | - | Barranquilla FC | 4:1 |  |
Colombia