| 2. Round | 15/09/2021 | PSV Eindhoven [Youth B] | - | sc Heerenveen [Youth B] | 3:1 | ||||
| 3. Round | 18/09/2021 | Feyenoord [Youth B] | - | PSV Eindhoven [Youth B] | 1:3 | ||||
| 4. Round | 24/09/2021 | PSV Eindhoven [Youth B] | - | FC Utrecht [Youth B] | 1:1 |  |
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| 5. Round | 02/10/2021 | PEC Zwolle [Youth B] | - | PSV Eindhoven [Youth B] | 0:2 | |
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| 6. Round | 16/10/2021 | PSV Eindhoven [Youth B] | - | NEC Nijmegen [Youth B] | 5:0 | ||||
| 7. Round | 23/10/2021 | AZ Alkmaar [Youth B] | - | PSV Eindhoven [Youth B] | 1:1 | ||||
| 8. Round | 30/10/2021 | PSV Eindhoven [Youth B] | - | PEC Zwolle [Youth B] | 5:0 | |
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| 9. Round | 06/11/2021 | FC Utrecht [Youth B] | - | PSV Eindhoven [Youth B] | 0:5 | |
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| 10. Round | 20/11/2021 | PSV Eindhoven [Youth B] | - | AZ Alkmaar [Youth B] | 2:1 | ||||
| 11. Round | 27/11/2021 | sc Heerenveen [Youth B] | - | PSV Eindhoven [Youth B] | 4:8 | |
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| 1. Round | 04/12/2021 | AFC Ajax [Youth B] | - | PSV Eindhoven [Youth B] | 2:2 | |
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| 13. Round | 11/12/2021 | PSV Eindhoven [Youth B] | - | Feyenoord [Youth B] | 6:1 | |
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| 14. Round | 18/12/2021 | NEC Nijmegen [Youth B] | - | PSV Eindhoven [Youth B] | 2:11 | |
Netherlands