| 1. Round | 22/01/2022 | Diriangén FC | - | UNAN Managua | 4:0 | ||||
| 4. Round | 13/02/2022 | Real Madriz | - | UNAN Managua | 0:1 | ||||
| 7. Round | 04/03/2022 | Real Estelí FC | - | UNAN Managua | 3:0 | ||||
| 9. Round | 10/03/2022 | UNAN Managua | - | Juventus Managua | 1:2 | ||||
| 14. Round | 11/04/2022 | CD Walter Ferretti | - | UNAN Managua | 4:1 |
Nicaragua