| 11. Round | 03/03/2021 | Sporting FC | - | Municipal Pérez Zeledón | 0:1 | ||||
| 12. Round | 06/03/2021 | Municipal Pérez Zeledón | - | LD Alajuelense | 1:5 | ||||
| 13. Round | 14/03/2021 | Municipal Pérez Zeledón | - | Santos de Guápiles | 1:1 | ||||
| 14. Round | 20/03/2021 | CS Cartaginés | - | Municipal Pérez Zeledón | 0:0 | ||||
| 16. Round | 05/04/2021 | Jicaral | - | Municipal Pérez Zeledón | 1:1 | ||||
| 17. Round | 11/04/2021 | Deportivo Saprissa | - | Municipal Pérez Zeledón | 1:1 | ||||
| 15. Round | 15/04/2021 | Municipal Pérez Zeledón | - | Municipal Grecia | 1:1 | ||||
| 18. Round | 18/04/2021 | Municipal Pérez Zeledón | - | Limón FC | 3:2 | ||||
| 19. Round | 21/04/2021 | Guadalupe | - | Municipal Pérez Zeledón | 0:1 | ||||
| 20. Round | 27/04/2021 | AD San Carlos | - | Municipal Pérez Zeledón | 0:1 | ||||
| 21. Round | 02/05/2021 | Municipal Pérez Zeledón | - | CS Herediano | 0:3 | ||||
| 22. Round | 13/05/2021 | Municipal Pérez Zeledón | - | Sporting FC | 3:1 |
Costa Rica