| 1. Round | 04/02/2022 | Universidad Técnica | - | Sport Boys | 2:1 | ||||
| 6. Round | 13/03/2022 | Sport Boys | - | Deportivo Municipal | 1:2 | ||||
| 7. Round | 19/03/2022 | Cienciano | - | Sport Boys | 4:1 | ||||
| 8. Round | 02/04/2022 | Sport Boys | - | Deportivo Binacional | 1:3 |  |
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| 16. Round | 05/06/2022 | Sporting Cristal | - | Sport Boys | 3:0 | ||||
| 17. Round | 19/06/2022 | Sport Boys | - | FBC Melgar | 0:1 | |
Peru