| 4. Round | 15/02/2022 | Real Cartagena | - | Atlético Huila | 1:1 |  |
|||
| 5. Round | 20/02/2022 | Atlético Huila | - | Real Santander | 1:1 | ||||
| 6. Round | 28/02/2022 | Atlético FC | - | Atlético Huila | 1:0 | ||||
| 7. Round | 07/03/2022 | Atlético Huila | - | Leones FC | 1:1 | ||||
| 8. Round | 11/03/2022 | Bogotá FC | - | Atlético Huila | 2:0 |
Colombia