| 1. Round | 17/07/2021 | Academia Cantolao | - | Sporting Cristal | 2:4 |  |
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| 3. Round | 30/07/2021 | Deportivo Municipal | - | Sporting Cristal | 1:1 | |
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| 4. Round | 04/08/2021 | Sporting Cristal | - | Universitario de Deportes | 2:2 | ||||
| 6. Round | 14/08/2021 | Sporting Cristal | - | Universidad Cesar Vallejo | 0:1 | ||||
| 8. Round | 23/08/2021 | Sporting Cristal | - | Cusco FC | 4:1 | ||||
| 9. Round | 27/08/2021 | FBC Melgar | - | Sporting Cristal | 0:1 | ||||
| 2. Round | 03/09/2021 | Sporting Cristal | - | Universidad San Martín | 1:1 | ||||
| 10. Round | 12/09/2021 | Sporting Cristal | - | Alianza Atlético | 5:2 | ||||
| 11. Round | 17/09/2021 | Universidad Técnica | - | Sporting Cristal | 1:6 | ||||
| 14. Round | 01/10/2021 | Cienciano | - | Sporting Cristal | 2:1 | ||||
| 7. Round | 08/10/2021 | Deportivo Binacional | - | Sporting Cristal | 3:4 | ||||
| 15. Round | 17/10/2021 | Sporting Cristal | - | Ayacucho FC | 1:0 | |
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| 17. Round | 30/10/2021 | Sporting Cristal | - | Sport Boys | 1:1 |
Venezuela