3. Round | 06/02/2022 | Fortaleza FC | - | Real Santander | 2:3 | ||||
4. Round | 13/02/2022 | Real Santander | - | Barranquilla FC | 2:3 | ||||
5. Round | 20/02/2022 | Atlético Huila | - | Real Santander | 1:1 | ||||
6. Round | 27/02/2022 | Real Santander | - | Real Cartagena | 1:2 | ||||
9. Round | 21/03/2022 | Real Santander | - | Leones FC | 0:4 | ||||
10. Round | 26/03/2022 | Bogotá FC | - | Real Santander | 2:1 | ||||
11. Round | 03/04/2022 | Real Santander | - | Orsomarso SC | 0:0 | ||||
12. Round | 10/04/2022 | Llaneros FC | - | Real Santander | 2:2 | ||||
13. Round | 16/04/2022 | Real Santander | - | Deportes Quindío | 0:1 |