| 4. Round | 30/07/2022 | Llaneros FC | - | Barranquilla FC | 1:1 | ||||
| 5. Round | 03/08/2022 | Barranquilla FC | - | Boca Juniors de Cali | 1:1 | ||||
| 6. Round | 09/08/2022 | Barranquilla FC | - | Leones FC | 3:1 | ||||
| 7. Round | 13/08/2022 | Bogotá FC | - | Barranquilla FC | 1:0 |  |
|||
| 8. Round | 20/08/2022 | Barranquilla FC | - | Deportes Quindío | 1:1 | ||||
| 9. Round | 31/08/2022 | Real Cartagena | - | Barranquilla FC | 2:2 | ||||
| 10. Round | 03/09/2022 | Barranquilla FC | - | Atlético Huila | 2:1 |  |
|||
| 12. Round | 14/09/2022 | Barranquilla FC | - | Real Santander | 2:1 | |
Colombia