| 2. Round | 23/01/2021 | Leones FC | - | Fortaleza FC | 0:0 | ||||
| 3. Round | 30/01/2021 | Fortaleza FC | - | Atlético Huila | 3:4 | ||||
| 5. Round | 10/02/2021 | Fortaleza FC | - | Atlético FC | 1:1 | ||||
| 6. Round | 15/02/2021 | Barranquilla FC | - | Fortaleza FC | 1:2 | ||||
| 7. Round | 23/02/2021 | Fortaleza FC | - | Valledupar FC | 3:2 | ||||
| 8. Round | 27/02/2021 | Llaneros FC | - | Fortaleza FC | 2:1 |  |
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| 10. Round | 07/03/2021 | Deportes Quindío | - | Fortaleza FC | 2:1 | ||||
| 11. Round | 14/03/2021 | Fortaleza FC | - | Orsomarso SC | 3:1 |
Colombia