| 3. Round | 22/07/2022 | Atlético Huila | - | Real Cartagena | 2:3 | ||||
| 4. Round | 29/07/2022 | Real Cartagena | - | Cúcuta Deportivo | 1:2 | ||||
| 5. Round | 04/08/2022 | Real Cartagena | - | Orsomarso SC | 0:1 | ||||
| 6. Round | 07/08/2022 | Fortaleza FC | - | Real Cartagena | 3:1 | ||||
| 8. Round | 24/08/2022 | Boyacá Chicó | - | Real Cartagena | 4:0 | ||||
| 13. Round | 20/09/2022 | Real Cartagena | - | Deportes Quindío | 3:1 | ||||
| 14. Round | 24/09/2022 | Barranquilla FC | - | Real Cartagena | 2:3 | ||||
| 15. Round | 01/10/2022 | Real Cartagena | - | Boca Juniors de Cali | 0:0 |
Colombia