| 1. Round | 19/01/2025 | Real España | - | Deportivo Génesis | 1:1 | ||||
| 2. Round | 26/01/2025 | Real Sociedad | - | Real España | 0:2 | ||||
| 3. Round | 30/01/2025 | Real España | - | Olimpia | 1:0 |  |
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| 5. Round | 08/02/2025 | Real España | - | Marathón | 1:2 | ||||
| 6. Round | 13/02/2025 | Lobos UPNFM | - | Real España | 3:4 | |
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| 8. Round | 23/02/2025 | Real España | - | Motagua | 2:0 | |
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| 4. Round | 26/02/2025 | Juticalpa | - | Real España | 0:1 | ||||
| 9. Round | 01/03/2025 | Olancho FC | - | Real España | 0:3 | ||||
| 10. Round | 06/03/2025 | Deportivo Génesis | - | Real España | 2:0 | ||||
| 11. Round | 14/03/2025 | Real España | - | Real Sociedad | 1:1 | ||||
| 12. Round | 31/03/2025 | Olimpia | - | Real España | 1:1 | |
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| 14. Round | 07/04/2025 | Marathón | - | Real España | 1:0 | ||||
| 15. Round | 13/04/2025 | Real España | - | Lobos UPNFM | 2:1 | ||||
| 16. Round | 21/04/2025 | Victoria | - | Real España | 1:1 | |
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| 17. Round | 27/04/2025 | Motagua | - | Real España | 1:1 |
Honduras