| 2. Round | 01/05/2021 | Guizhou FC | - | Suzhou Dongwu | 1:0 | ||||
| 3. Round | 06/05/2021 | Wuhan Three Towns | - | Guizhou FC | 0:1 | ||||
| 6. Round | 20/05/2021 | Guizhou FC | - | Liaoning Shenyang Urban FC | 0:2 | ||||
| 9. Round | 04/06/2021 | Heilongjiang Ice City | - | Guizhou FC | 0:0 | ||||
| 10. Round | 10/06/2021 | Guizhou FC | - | Beijing BIT | 3:1 |  |
|||
| 12. Round | 18/07/2021 | Guizhou FC | - | Shaanxi Chang'an Athletic | 3:1 |  |
|||
| 13. Round | 22/07/2021 | Guizhou FC | - | Jiangxi Beidamen | 0:0 | |
|||
| 15. Round | 01/08/2021 | Guizhou FC | - | Sichuan Jiuniu | 0:0 | |
|||
| 16. Round | 07/08/2021 | Shaanxi Chang'an Athletic | - | Guizhou FC | 4:1 | ||||
| 17. Round | 12/08/2021 | Jiangxi Beidamen | - | Guizhou FC | 0:1 | ||||
| 18. Round | 17/08/2021 | Guizhou FC | - | Nanjing City | 1:2 | ||||
| 19. Round | 05/09/2021 | Nantong Zhiyun | - | Guizhou FC | 0:1 | |
|||
| 24. Round | 26/09/2021 | Xinjiang Tianshan Leopard | - | Guizhou FC | 1:1 | ||||
| 25. Round | 30/09/2021 | Guizhou FC | - | Zibo Cuju | 1:2 | |
|||
| 26. Round | 04/10/2021 | Beijing BSU | - | Guizhou FC | 1:1 | |
|||
| 27. Round | 22/11/2021 | Meizhou Hakka | - | Guizhou FC | 4:2 | ||||
| 28. Round | 25/11/2021 | Guizhou FC | - | Zhejiang Professional | 0:0 | ||||
| 29. Round | 29/11/2021 | Guizhou FC | - | Kunshan FC | 0:4 |
China